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    <notes>
      <body xmlns="http://www.w3.org/1999/xhtml">
        <p>From Pritchard and Kell (2002) Eur. J. Biochem. 269, 3894-3904 which was</p>
        <p>modified from Teusink et al. (2000) Eur J Biochem 267, 5313-5329. </p>
        <p>This version uses the Vmaxes found by the best fit (R1) of Table 1 of the </p>
        <p>Pritchard and Kell paper, and simulates a decrease of external glucose  concentration from 100 to 2 mM.</p>
        <p>(More model files at http://users.aber.ac.uk/lep/models.shtml)</p>
        <p>This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2006 The BioModels Team.
        <br/> For more information see the 
        <a href="http://www.ebi.ac.uk/biomodels/legal.html">terms of use</a>.</p>
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        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000036" id="PGK">
        <listOfReactants>
          <speciesReference species="ADP"/>
          <speciesReference species="BPG"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="ATP"/>
          <speciesReference species="P3G"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Vmax_8 </ci>
                <apply>
                  <divide/>
                  <apply>
                    <minus/>
                    <apply>
                      <times/>
                      <ci> Keq_8 </ci>
                      <ci> BPG </ci>
                      <ci> ADP </ci>
                    </apply>
                    <apply>
                      <times/>
                      <ci> P3G </ci>
                      <ci> ATP </ci>
                    </apply>
                  </apply>
                  <apply>
                    <times/>
                    <ci> Kp3g_8 </ci>
                    <ci> Katp_8 </ci>
                  </apply>
                </apply>
              </apply>
              <apply>
                <times/>
                <apply>
                  <plus/>
                  <cn type="integer"> 1 </cn>
                  <apply>
                    <divide/>
                    <ci> BPG </ci>
                    <ci> Kbpg_8 </ci>
                  </apply>
                  <apply>
                    <divide/>
                    <ci> P3G </ci>
                    <ci> Kp3g_8 </ci>
                  </apply>
                </apply>
                <apply>
                  <plus/>
                  <cn type="integer"> 1 </cn>
                  <apply>
                    <divide/>
                    <ci> ADP </ci>
                    <ci> Kadp_8 </ci>
                  </apply>
                  <apply>
                    <divide/>
                    <ci> ATP </ci>
                    <ci> Katp_8 </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Vmax_8" value="1288"/>
            <parameter id="Keq_8" value="3200"/>
            <parameter id="Kp3g_8" value="0.53"/>
            <parameter id="Katp_8" value="0.3"/>
            <parameter id="Kbpg_8" value="0.003"/>
            <parameter id="Kadp_8" value="0.2"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000037" id="PGM">
        <listOfReactants>
          <speciesReference species="P3G"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="P2G"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Vmax_9 </ci>
                <apply>
                  <minus/>
                  <apply>
                    <divide/>
                    <ci> P3G </ci>
                    <ci> Kp3g_9 </ci>
                  </apply>
                  <apply>
                    <divide/>
                    <ci> P2G </ci>
                    <apply>
                      <times/>
                      <ci> Kp3g_9 </ci>
                      <ci> Keq_9 </ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <plus/>
                <cn type="integer"> 1 </cn>
                <apply>
                  <divide/>
                  <ci> P3G </ci>
                  <ci> Kp3g_9 </ci>
                </apply>
                <apply>
                  <divide/>
                  <ci> P2G </ci>
                  <ci> Kp2g_9 </ci>
                </apply>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Vmax_9" value="2585"/>
            <parameter id="Kp3g_9" value="1.2"/>
            <parameter id="Keq_9" value="0.19"/>
            <parameter id="Kp2g_9" value="0.08"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000038" id="ENO">
        <listOfReactants>
          <speciesReference species="P2G"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="PEP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Vmax_10 </ci>
                <apply>
                  <minus/>
                  <apply>
                    <divide/>
                    <ci> P2G </ci>
                    <ci> Kp2g_10 </ci>
                  </apply>
                  <apply>
                    <divide/>
                    <ci> PEP </ci>
                    <apply>
                      <times/>
                      <ci> Kp2g_10 </ci>
                      <ci> Keq_10 </ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <plus/>
                <cn type="integer"> 1 </cn>
                <apply>
                  <divide/>
                  <ci> P2G </ci>
                  <ci> Kp2g_10 </ci>
                </apply>
                <apply>
                  <divide/>
                  <ci> PEP </ci>
                  <ci> Kpep_10 </ci>
                </apply>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Vmax_10" value="201.6"/>
            <parameter id="Kp2g_10" value="0.04"/>
            <parameter id="Keq_10" value="6.7"/>
            <parameter id="Kpep_10" value="0.5"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000039" id="PYK">
        <listOfReactants>
          <speciesReference species="ADP"/>
          <speciesReference species="PEP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="ATP"/>
          <speciesReference species="PYR"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Vmax_11 </ci>
                <apply>
                  <minus/>
                  <apply>
                    <divide/>
                    <apply>
                      <times/>
                      <ci> PEP </ci>
                      <ci> ADP </ci>
                    </apply>
                    <apply>
                      <times/>
                      <ci> Kpep_11 </ci>
                      <ci> Kadp_11 </ci>
                    </apply>
                  </apply>
                  <apply>
                    <divide/>
                    <apply>
                      <times/>
                      <ci> PYR </ci>
                      <ci> ATP </ci>
                    </apply>
                    <apply>
                      <times/>
                      <ci> Kpep_11 </ci>
                      <ci> Kadp_11 </ci>
                      <ci> Keq_11 </ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <times/>
                <apply>
                  <plus/>
                  <cn type="integer"> 1 </cn>
                  <apply>
                    <divide/>
                    <ci> PEP </ci>
                    <ci> Kpep_11 </ci>
                  </apply>
                  <apply>
                    <divide/>
                    <ci> PYR </ci>
                    <ci> Kpyr_11 </ci>
                  </apply>
                </apply>
                <apply>
                  <plus/>
                  <cn type="integer"> 1 </cn>
                  <apply>
                    <divide/>
                    <ci> ADP </ci>
                    <ci> Kadp_11 </ci>
                  </apply>
                  <apply>
                    <divide/>
                    <ci> ATP </ci>
                    <ci> Katp_11 </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Vmax_11" value="1000"/>
            <parameter id="Kpep_11" value="0.14"/>
            <parameter id="Kadp_11" value="0.53"/>
            <parameter id="Keq_11" value="6500"/>
            <parameter id="Kpyr_11" value="21"/>
            <parameter id="Katp_11" value="1.5"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000040" id="PDC" reversible="false">
        <listOfReactants>
          <speciesReference species="PYR"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="AcAld"/>
          <speciesReference species="CO2"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Vmax_12 </ci>
                <apply>
                  <power/>
                  <apply>
                    <divide/>
                    <ci> PYR </ci>
                    <ci> Kpyr_12 </ci>
                  </apply>
                  <ci> nH_12 </ci>
                </apply>
              </apply>
              <apply>
                <plus/>
                <cn type="integer"> 1 </cn>
                <apply>
                  <power/>
                  <apply>
                    <divide/>
                    <ci> PYR </ci>
                    <ci> Kpyr_12 </ci>
                  </apply>
                  <ci> nH_12 </ci>
                </apply>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Vmax_12" value="857.8"/>
            <parameter id="Kpyr_12" value="4.33"/>
            <parameter id="nH_12" value="1.9"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000041" id="ADH">
        <listOfReactants>
          <speciesReference species="NAD"/>
          <speciesReference species="EtOH"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="NADH"/>
          <speciesReference species="AcAld"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Vmax_13 </ci>
                <apply>
                  <minus/>
                  <apply>
                    <divide/>
                    <apply>
                      <times/>
                      <ci> EtOH </ci>
                      <ci> NAD </ci>
                    </apply>
                    <apply>
                      <times/>
                      <ci> Ketoh_13 </ci>
                      <ci> Kinad_13 </ci>
                    </apply>
                  </apply>
                  <apply>
                    <divide/>
                    <apply>
                      <times/>
                      <ci> AcAld </ci>
                      <ci> NADH </ci>
                    </apply>
                    <apply>
                      <times/>
                      <ci> Ketoh_13 </ci>
                      <ci> Kinad_13 </ci>
                      <ci> Keq_13 </ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <plus/>
                <cn type="integer"> 1 </cn>
                <apply>
                  <divide/>
                  <ci> NAD </ci>
                  <ci> Kinad_13 </ci>
                </apply>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <ci> EtOH </ci>
                    <ci> Knad_13 </ci>
                  </apply>
                  <apply>
                    <times/>
                    <ci> Kinad_13 </ci>
                    <ci> Ketoh_13 </ci>
                  </apply>
                </apply>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <ci> AcAld </ci>
                    <ci> Knadh_13 </ci>
                  </apply>
                  <apply>
                    <times/>
                    <ci> Kinadh_13 </ci>
                    <ci> Kacald_13 </ci>
                  </apply>
                </apply>
                <apply>
                  <divide/>
                  <ci> NADH </ci>
                  <ci> Kinadh_13 </ci>
                </apply>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <ci> EtOH </ci>
                    <ci> NAD </ci>
                  </apply>
                  <apply>
                    <times/>
                    <ci> Kinad_13 </ci>
                    <ci> Ketoh_13 </ci>
                  </apply>
                </apply>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <ci> NAD </ci>
                    <ci> AcAld </ci>
                    <ci> Knadh_13 </ci>
                  </apply>
                  <apply>
                    <times/>
                    <ci> Kinad_13 </ci>
                    <ci> Kinadh_13 </ci>
                    <ci> Kacald_13 </ci>
                  </apply>
                </apply>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <ci> EtOH </ci>
                    <ci> NADH </ci>
                    <ci> Knad_13 </ci>
                  </apply>
                  <apply>
                    <times/>
                    <ci> Kinad_13 </ci>
                    <ci> Kinadh_13 </ci>
                    <ci> Ketoh_13 </ci>
                  </apply>
                </apply>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <ci> AcAld </ci>
                    <ci> NADH </ci>
                  </apply>
                  <apply>
                    <times/>
                    <ci> Kacald_13 </ci>
                    <ci> Kinadh_13 </ci>
                  </apply>
                </apply>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <ci> EtOH </ci>
                    <ci> NAD </ci>
                    <ci> AcAld </ci>
                  </apply>
                  <apply>
                    <times/>
                    <ci> Kinad_13 </ci>
                    <ci> Kiacald_13 </ci>
                    <ci> Ketoh_13 </ci>
                  </apply>
                </apply>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <ci> EtOH </ci>
                    <ci> AcAld </ci>
                    <ci> NADH </ci>
                  </apply>
                  <apply>
                    <times/>
                    <ci> Kietoh_13 </ci>
                    <ci> Kinadh_13 </ci>
                    <ci> Kacald_13 </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Vmax_13" value="209.5"/>
            <parameter id="Ketoh_13" value="17"/>
            <parameter id="Kinad_13" value="0.92"/>
            <parameter id="Keq_13" value="6.9e-05"/>
            <parameter id="Knad_13" value="0.17"/>
            <parameter id="Knadh_13" value="0.11"/>
            <parameter id="Kinadh_13" value="0.031"/>
            <parameter id="Kacald_13" value="1.11"/>
            <parameter id="Kiacald_13" value="1.1"/>
            <parameter id="Kietoh_13" value="90"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000042" id="ATPase" reversible="false">
        <listOfReactants>
          <speciesReference species="ATP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="ADP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> Katpase_14 </ci>
              <ci> ATP </ci>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Katpase_14" value="39.5"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000043" id="AK">
        <listOfReactants>
          <speciesReference species="ADP" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="ATP"/>
          <speciesReference species="AMP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> k1_15 </ci>
                <ci> ADP </ci>
                <ci> ADP </ci>
              </apply>
              <apply>
                <times/>
                <ci> k2_15 </ci>
                <ci> ATP </ci>
                <ci> AMP </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="k1_15" value="45"/>
            <parameter id="k2_15" value="100"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000044" id="G3PDH" reversible="false">
        <listOfReactants>
          <speciesReference species="DHAP"/>
          <speciesReference species="NADH"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="NAD"/>
          <speciesReference species="Glycerol"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Vmax_16 </ci>
                <apply>
                  <minus/>
                  <apply>
                    <times/>
                    <apply>
                      <divide/>
                      <ci> DHAP </ci>
                      <ci> Kdhap_16 </ci>
                    </apply>
                    <apply>
                      <divide/>
                      <ci> NADH </ci>
                      <ci> Knadh_16 </ci>
                    </apply>
                  </apply>
                  <apply>
                    <times/>
                    <apply>
                      <divide/>
                      <ci> Glycerol </ci>
                      <ci> Kdhap_16 </ci>
                    </apply>
                    <apply>
                      <divide/>
                      <ci> NAD </ci>
                      <ci> Knadh_16 </ci>
                    </apply>
                    <apply>
                      <divide/>
                      <cn type="integer"> 1 </cn>
                      <ci> Keq_16 </ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <times/>
                <apply>
                  <plus/>
                  <cn type="integer"> 1 </cn>
                  <apply>
                    <divide/>
                    <ci> DHAP </ci>
                    <ci> Kdhap_16 </ci>
                  </apply>
                  <apply>
                    <divide/>
                    <ci> Glycerol </ci>
                    <ci> Kglycerol_16 </ci>
                  </apply>
                </apply>
                <apply>
                  <plus/>
                  <cn type="integer"> 1 </cn>
                  <apply>
                    <divide/>
                    <ci> NADH </ci>
                    <ci> Knadh_16 </ci>
                  </apply>
                  <apply>
                    <divide/>
                    <ci> NAD </ci>
                    <ci> Knad_16 </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Vmax_16" value="47.11"/>
            <parameter id="Kdhap_16" value="0.4"/>
            <parameter id="Knadh_16" value="0.023"/>
            <parameter id="Keq_16" value="4300"/>
            <parameter id="Kglycerol_16" value="1"/>
            <parameter id="Knad_16" value="0.93"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000045" id="Glycogen_Branch" reversible="false">
        <listOfReactants>
          <speciesReference species="ATP"/>
          <speciesReference species="G6P"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="ADP"/>
          <speciesReference species="Glycogen"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <ci> KGLYCOGEN_17 </ci>
          </math>
          <listOfParameters>
            <parameter id="KGLYCOGEN_17" value="6"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000046" id="Trehalose_Branch" reversible="false">
        <listOfReactants>
          <speciesReference species="ATP"/>
          <speciesReference species="G6P" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="ADP"/>
          <speciesReference species="Trehalose"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <ci> Ktrehalose_18 </ci>
          </math>
          <listOfParameters>
            <parameter id="Ktrehalose_18" value="2.4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000047" id="Succinate_Branch" reversible="false">
        <listOfReactants>
          <speciesReference species="NAD" stoichiometry="3"/>
          <speciesReference species="AcAld" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="NADH" stoichiometry="3"/>
          <speciesReference species="Succinate"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k_19 </ci>
              <ci> AcAld </ci>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="k_19" value="21.4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>
